Protein Binding of Beta - Lactam Antibiotics in Critically Ill Patients : Can we successfully
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چکیده
Protein Binding of Beta-Lactam Antibiotics in Critically Ill Patients: Can we successfully 1 predict unbound concentrations? 2 3 Gloria Wong a , Scott Briscoe b , Syamhanin Adnan a , Brett McWhinney b , Jacobus Ungerer b , 4 Jeffrey Lipman a,c , Jason A. Roberts a,c# 5 6 a Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, 7 Queensland, Australia 8 b Chemical Pathology, Pathology Queensland, Brisbane, Queensland, Australia 9 c Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia 10 11
منابع مشابه
Protein binding of β-lactam antibiotics in critically ill patients: can we successfully predict unbound concentrations?
The use of therapeutic drug monitoring (TDM) to optimize beta-lactam dosing in critically ill patients is growing in popularity, although there are limited data describing the potential impact of altered protein binding on achievement of target concentrations. The aim of this study was to compare the measured unbound concentration to the unbound concentration predicted from published protein bi...
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تاریخ انتشار 2013